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    • Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals 

      Howe, Anita Y.M.; Rodrigo, Chaturaka; Cunningham, Evan B.; Douglas, Mark W.; Dietz, Julia; Grebely, Jason; Popping, Stephanie; Sfalcin, Javier Alejandro; Parczewski, Milosz; Sarrazin, Christoph; de Salazar, Adolfo; Fuentes, Ana; Sayan, Murat; Quer, Josep; Kjellin, Midori; Kileng, Hege; Mor, Orna; Lennerstrand, Johan; Fourati, Slim; Di Maio, Velia Chiara; Chulanov, Vladimir; Pawlotsky, Jean-Michel; Harrigan, P. Richard; Ceccherini-Silberstein, Francesca; Garcia, Federico (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-24)
      Background & Aims: Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment options and risking onward resistant virus transmission. In this study, we evaluated RAS prevalence and distribution, including novel NS5A RASs and ...